AGR2, an Endoplasmic Reticulum Protein, Is Secreted into the Gastrointestinal Mucus
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چکیده
منابع مشابه
AGR2, an Endoplasmic Reticulum Protein, Is Secreted into the Gastrointestinal Mucus
The MUC2 mucin is the major constituent of the two mucus layers in colon. Mice lacking the disulfide isomerase-like protein Agr2 have been shown to be more susceptible to colon inflammation. The Agr2(-/-) mice have less filled goblet cells and were now shown to have a poorly developed inner colon mucus layer. We could not show AGR2 covalently bound to recombinant MUC2 N- and C-termini as have p...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0104186